A convenient and practical synthesis of β-diketones bearing linear perfluorinated alkyl groups and a 2-thienyl moiety

• Ilya V. Taydakov,
• Yuliya M. Kreshchenova and
• Ekaterina P. Dolotova

Beilstein J. Org. Chem. 2018, 14, 3106–3111, doi:10.3762/bjoc.14.290

• condensation; copper chelate; β-diketones; perfluorinated esters; thiophene; Introduction Classical β-diketones have been studied for more than a century, and no doubt, they are the most popular O,O-ligands in the coordination chemistry of d- and f-elements [1][2][3]. These compounds are widely used as

• fluorinated β-diketone was mentioned in the pioneering works of Henne at al. concerning the Claisen condensation of perfluorinated esters [29]. Since preparation of active alkoxides is cumbersome and the yields are unstable with commercial reagents, NaH was tested as an alternative base. The preliminary

• solvent. Additional advantages of THF include its high miscibility with both 2-acetylthiophene and even long-chain perfluorinated esters, and the high solubility of sodium enolates in it. This fact makes it possible to obtain homogeneous reaction mixtures after completion of condensation. The optimum